Closed-loop effects in coupling cardiac physiological models to clinical interventions

Husmeier, D. and Paun, L. M. (2020) Closed-loop effects in coupling cardiac physiological models to clinical interventions. In: Irigoien, I., Lee, D.-J., Martínez-Minaya, J. and Rodríguez-Álvarez, M. X. (eds.) Proceedings of the 35th International Workshop on Statistical Modelling. Servicio Editorial de la Universidad del País Vasco: Bilbao, Spain, pp. 120-125. ISBN 9788413192673

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Abstract

There have been impressive methodological advancements in the mathematical modelling of cardio-physiological processes. The majority of recent articles have focused on the forward problem: developing flexible mathematical models and robust numerical simulation procedures to match characteristics of physiological target data, and the inverse problem: inferring model parameters from cardiac physiological data with reliable uncertainty quantification. However, when connecting mathematical model predictions to the clinical decision process, new challenges arise. This paper briefly discusses the complications that poten- tially result from closed-loop effects, and the model extensions that are required to reduce the ensuing bias.

Item Type:Book Sections
Keywords:Closed-loop effect, physiological model, pulmonary hypertension.
Status:Published
Glasgow Author(s) Enlighten ID:Paun, Miss Luiza Mihaela and Husmeier, Professor Dirk
Authors: Husmeier, D., and Paun, L. M.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Statistics
Publisher:Servicio Editorial de la Universidad del País Vasco
ISBN:9788413192673
Copyright Holders:Copyright © 2020 Servicio Editorial de la Universidad del País Vasco Euskal Herriko Unibertsitateko Argitalpen Zerbitzua
First Published:First published in Proceedings of the 35th International Workshop on Statistical Modelling. Volume 1: 120-125
Publisher Policy:Reproduced in accordance with the publisher copyright policy
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
300982Exploiting Closed-Loop Aspects in Computationally and Data Intensive AnalyticsRoderick Murray-SmithEngineering and Physical Sciences Research Council (EPSRC)EP/R018634/1Computing Science
303232EPSRC Centre for Multiscale soft tissue mechanics with MIT and POLIMI (SofTMech-MP)Xiaoyu LuoEngineering and Physical Sciences Research Council (EPSRC)EP/S030875/1M&S - Mathematics
172141EPSRC Centre for Multiscale soft tissue mechanics with application to heart & cancerRaymond OgdenEngineering and Physical Sciences Research Council (EPSRC)EP/N014642/1M&S - Mathematics
305655Inference of cardio-mechanical parameters in real time: moving mathematical modelling into the clinicDirk HusmeierThe Royal Society of Edinburgh (ROYSOCED)62335M&S - Statistics