Gut γδ T cells as guardians, disruptors and instigators of cancer

Suzuki, T., Hayman, L., Kilbey, A., Edwards, J. and Coffelt, S. B. (2020) Gut γδ T cells as guardians, disruptors and instigators of cancer. Immunological Reviews, 298(1), pp. 198-217. (doi: 10.1111/imr.12916) (PMID:32840001)

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Colorectal cancer is the third most common cancer worldwide with nearly 2 million cases per year. Immune cells and inflammation are a critical component of colorectal cancer progression, and they are used as reliable prognostic indicators of patient outcome. With the growing appreciation for immunology in colorectal cancer, interest is growing on the role γδ T cells have to play, as they represent one of the most prominent immune cell populations in gut tissue. This group of cells consists of both resident populations—γδ intraepithelial lymphocytes (γδ IELs)—and transient populations that each has unique functions. The homeostatic role of these γδ T cell subsets is to maintain barrier integrity and prevent microorganisms from breaching the mucosal layer, which is accomplished through crosstalk with enterocytes and other immune cells. Recent years have seen a surge in discoveries regarding the regulation of γδ IELs in the intestine and the colon with particular new insights into the butyrophilin family. In this review, we discuss the development, specialities, and functions of γδ T cell subsets during cancer progression. We discuss how these cells may be used to predict patient outcome, as well as how to exploit their behavior for cancer immunotherapy.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hayman, Liam and Edwards, Professor Joanne and Coffelt, Dr Seth and Kilbey, Dr Anna
Authors: Suzuki, T., Hayman, L., Kilbey, A., Edwards, J., and Coffelt, S. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Immunological Reviews
ISSN (Online):1600-065X
Published Online:24 August 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Immunological Reviews 298(1): 198-217
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174115CRUK Centre RenewalOwen SansomCancer Research UK (CRUK)C7932/A25142CS - Beatson Institute for Cancer Research
301010understanding gamma delta T cell function in colorectal cancer metastasisSeth CoffeltWellcome Trust (WELLCOTR)208990/Z/17/ZCS - Beatson Institute for Cancer Research