N-terminal pro-B-type natriuretic peptide by itself predicts death and cardiovascular events in high-risk patients with type 2 diabetes

Malachias, M. V.B. et al. (2020) N-terminal pro-B-type natriuretic peptide by itself predicts death and cardiovascular events in high-risk patients with type 2 diabetes. Journal of the American Heart Association, 9(19), e017462. (doi: 10.1161/JAHA.120.017462) (PMID:32964800) (PMCID:PMC7792415)

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Abstract

Background: NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) improves the discriminatory ability of risk‐prediction models in type 2 diabetes mellitus (T2DM) but is not yet used in clinical practice. We assessed the discriminatory strength of NT‐proBNP by itself for death and cardiovascular events in high‐risk patients with T2DM. Methods and Results: Cox proportional hazards were used to create a base model formed by 20 variables. The discriminatory ability of the base model was compared with that of NT‐proBNP alone and with NT‐proBNP added, using C‐statistics. We studied 5509 patients (with complete data) of 8561 patients with T2DM and cardiovascular and/or chronic kidney disease who were enrolled in the ALTITUDE (Aliskiren in Type 2 Diabetes Using Cardiorenal Endpoints) trial. During a median 2.6‐year follow‐up period, 469 patients died and 768 had a cardiovascular composite outcome (cardiovascular death, resuscitated cardiac arrest, nonfatal myocardial infarction, stroke, or heart failure hospitalization). NT‐proBNP alone was as discriminatory as the base model for predicting death (C‐statistic, 0.745 versus 0.744, P=0.95) and the cardiovascular composite outcome (C‐statistic, 0.723 versus 0.731, P=0.37). When NT‐proBNP was added, it increased the predictive ability of the base model for death (C‐statistic, 0.779 versus 0.744, P<0.001) and for cardiovascular composite outcome (C‐statistic, 0.763 versus 0.731, P<0.001). Conclusions: In high‐risk patients with T2DM, NT‐proBNP by itself demonstrated discriminatory ability similar to a multivariable model in predicting both death and cardiovascular events and should be considered for risk stratification.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jhund, Dr Pardeep and McMurray, Professor John
Authors: Malachias, M. V.B., Jhund, P., Claggett, B. L., Wijkman, M. O., Bentley-Lewis, R., Chaturvedi, N., Desai, A. S., Haffner, S. M., Parving, H.-H., Prescott, M. F., Solomon, S. D., De Zeeuw, D., McMurray, J. J.V., and Pfeffer, M. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences > Exercise Physiology/Sports Medicine
Journal Name:Journal of the American Heart Association
Publisher:on behalf of the American Heart Association, Inc., by Wiley Blackwell
ISSN:2047-9980
ISSN (Online):2047-9980
Published Online:23 September 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Journal of the American Heart Association 9:e017462
Publisher Policy:Reproduced under a Creative Commons Licence

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