Pulmonary hypertension

MacLean, M.R., Church, C., MacKenzie, A., Jayasekera, G. and Mair, K. (2019) Pulmonary hypertension. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 439-447. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_41)

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Abstract

Pulmonary arterial hypertension (PAH) is defined by a resting mean pulmonary artery pressure (PAP) >25 mm Hg, pulmonary vascular resistance (PVR) >3 Wood units, and pulmonary capillary wedge pressure <15 mm Hg (in the absence of other causes of PH). There are five categories of pulmonary hypertension (PH) in the latest World Health Organization classification (Simonneau G, Robbins IM, Beghetti M, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2009;54(1 Suppl):S43–54): (1) PAH (including heritable PAH and idiopathic PAH formally known as primary pulmonary hypertension (PPH)); (2) PH due to left heart disease; (3) PH due to lung diseases and/or hypoxia; (4) chronic thromboembolic PH (CTEPH); and (5) PH with unclear multifactorial mechanisms. The mortality rate of PAH remains high despite current treatment (Hoeper and Simon, Eur Respir Rev 23(134):450–457, 2014). Here we will review PAH, current knowledge of treatments, and evolving therapeutic approaches.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:MacLean, Professor Margaret and Jayasekera, Geeshath and Mair, Dr Kirsty
Authors: MacLean, M.R., Church, C., MacKenzie, A., Jayasekera, G., and Mair, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Publisher:Springer
ISBN:9783030164805
Published Online:03 August 2019

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