Renal disease

Mark, P. B. and Denby, L. (2019) Renal disease. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 409-417. ISBN 9783030164805 (doi:10.1007/978-3-030-16481-2_38)

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Abstract

Chronic kidney disease (CKD) is common affecting 5–10% of the population. In clinical practice, classification of CKD is derived from kidney function measured as estimated glomerular filtration rate. CKD may progress towards end-stage kidney disease (ESKD) requiring treatment with dialysis or kidney transplantation. Treatable risk factors to reduce the risk of CKD progression include hypertension, proteinuria and therapy aimed at specific primary renal diseases. Patients with CKD and ESKD are at elevated cardiovascular risk. Some of this elevated cardiovascular risk can be attributed to a high prevalence of conventional cardiovascular risk factors being present in patients with CKD. However, a number of CKD-specific risk factors for cardiovascular disease are present including proteinuria, abnormalities of calcium-phosphate metabolism, left ventricular hypertrophy and anaemia. Targeting renal fibrosis may lead to fewer patients developing progressive CKD in the future.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Mark, Dr Patrick and Denby, Dr Laura
Authors: Mark, P. B., and Denby, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Publisher:Springer
ISBN:9783030164805
Published Online:03 August 2019

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