Heart failure with reduced ejection fraction

Jackson, A. M. and Jhund, P. S. (2019) Heart failure with reduced ejection fraction. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 383-395. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_36)

Abstract

Heart failure with reduced ejection fraction (HF-REF) is a common problem worldwide and its prevalence rises with age. It is associated with substantial morbidity and mortality. Development of the condition is driven by a number of haemodynamic and neurohumoral pathophysiological processes which, in turn, lead to adverse remodelling of the myocardium and worsening heart failure. In every case, there is an underlying aetiological factor which triggers this detrimental cascade. The mainstay of treatment is pharmacological, and in select patients this can be complemented by the use of implantable devices or other more approaches techniques. This chapter provides an overview of the pathophysiology of HF-REF, with a focus on the evidence-based treatments currently used.

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Jackson, Dr Alice and Jhund, Professor Pardeep
• Authors: Jackson, A. M., and Jhund, P. S.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Publisher: Springer
• ISBN: 9783030164805
• Published Online: 03 August 2019