Reactive oxygen species

de Lucca Camargo, L. and Touyz, R. M. (2019) Reactive oxygen species. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 127-136. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_12)

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Reactive oxygen species (ROS) are small unstable, highly reactive molecules with a short half-life derived by reduction of molecular oxygen. Once generated, ROS influence signalling molecules, in part through post-translational oxidative modification of proteins, modulating cellular function. These species are produced in all vascular cell types and have emerged as key second messengers in cellular events in the vasculature. ROS are involved in vascular contraction and relaxation, cell growth, migration, differentiation, survival and apoptosis. In pathological conditions, increased ROS generation is associated with oxidative stress and inflammation leading to dysregulation of vascular cell function and consequent vascular injury underlying cardiovascular diseases.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:De Lucca Camargo, Ms Livia and Touyz, Professor Rhian
Authors: de Lucca Camargo, L., and Touyz, R. M.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Published Online:03 August 2019

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