Nitric oxide

Leiper, J. (2019) Nitric oxide. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 117-126. ISBN 9783030164805 (doi:10.1007/978-3-030-16481-2_11)

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Nitric oxide (NO) is a mediator with protean functions. It is involved in signalling in the cardiovascular, gastrointestinal, genitourinary, respiratory and nervous systems, and disordered NO generation has been implicated in a wide range of diseases. NO has been described as a ‘goldilocks molecule’ in that just the right amount of NO is required for homeostasis with both over- or underproduction associated with pathology. Therapies based on increasing NO effects or donating exogenous NO hold promise, and several companies are developing compounds that inhibit overproduction of NO synthesis. In this chapter we will summarise the rationale for targeting NO synthesis and describe the current state of drug development in this area.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Leiper, Professor James
Authors: Leiper, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Published Online:03 August 2019

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