Does the association between physical capability and mortality differ by deprivation? Findings from the UK Biobank population-based cohort study

Rey-Lopez, J. P., Ho, F. K.W., Foster, H. M.E. , Petermann-Rocha, F., Sattar, N. , Pell, J. P. , Gill, J. M.R. , Gray, S. R. and Celis-Morales, C. A. (2020) Does the association between physical capability and mortality differ by deprivation? Findings from the UK Biobank population-based cohort study. Journal of Sports Sciences, (doi: 10.1080/02640414.2020.1797438) (PMID:32723006) (Early Online Publication)

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Abstract

Background: To investigate whether the excess risk of adverse health outcomes associated with a lower physical capability in adulthood differs by deprivation levels. Methods: 279,030 participants from the UK Biobank were included. Handgrip strength and walking pace were the exposures. All-cause mortality, CVD mortality and incidence were the outcomes. Townsend deprivation index was treated as a potential effect modifier. The associations were investigated using Cox-regression models with years of follow-up as the time-varying covariate. Results: A significant interaction between deprivation and handgrip strength was found for all-cause mortality (p = 0.024), CVD mortality (p = 0.006) and CVD incidence (p = 0.001). The hazard ratio for all-cause mortality was 1.18 [1.09; 1.29] per 1-tertile higher level of grip strength in the least deprived group, whereas it was 1.30 [1.18; 1.43] in the most deprived individuals. Similar results were found for CVD mortality and incidence per tertile increment in handgrip strength in the least and most deprived quintiles, respectively. No significant interactions between deprivation and walking pace were found for any of the outcomes. Conclusion: Low handgrip strength is a stronger predictor of morbidity and mortality in individuals living in more deprived areas.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos and Gray, Dr Stuart and Gill, Professor Jason and Ho, Dr Frederick and Foster, Dr Hamish and Pell, Professor Jill and Petermann, Mrs Fanny and Sattar, Professor Naveed
Authors: Rey-Lopez, J. P., Ho, F. K.W., Foster, H. M.E., Petermann-Rocha, F., Sattar, N., Pell, J. P., Gill, J. M.R., Gray, S. R., and Celis-Morales, C. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:Journal of Sports Sciences
Publisher:Taylor & Francis
ISSN:0264-0414
ISSN (Online):1466-447X
Published Online:29 July 2020
Copyright Holders:Copyright © 2020 Informa UK Limited, trading as Taylor & Francis Group
First Published:First published in Journal of Sports Sciences 2020
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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