Leonard, D. A. , McGrouther, D. A., Kurtz, J. M. and Cetrulo, C. L. (2012) Tolerance induction strategies in vascularized composite allotransplantation: mixed chimerism and novel developments. Clinical and Developmental Immunology, 2012, 863264. (doi: 10.1155/2012/863264) (PMID:23320020) (PMCID:PMC3540904)
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Abstract
Since the start of the clinical vascularized composite allotransplantation (VCA) era over a decade ago this field has witnessed significant developments in both basic and translational research. Transplant tolerance, defined as rejection-free acceptance of transplanted organs or tissues without long-term immunosuppression, holds the potential to revolutionize the field of VCA by removing the need for life-long immunosuppression. While tolerance of organ and vascularized composite transplants may be induced in small animal models by a variety of protocols, only mixed-chimerism-based protocols have successfully bridged the gap to preclinical study and to clinical trial in solid organ transplantation to date. In this paper we review the mixed-chimerism approach to tolerance induction, with specific reference to the field of VCA transplantation, and provide an overview of some novel cellular therapies as potential adjuvants to mixed chimerism in the development of tolerance induction protocols for clinical vascularized composite allotransplantation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Leonard, Dr David |
Authors: | Leonard, D. A., McGrouther, D. A., Kurtz, J. M., and Cetrulo, C. L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Clinical and Developmental Immunology |
Publisher: | Hindawi |
ISSN: | 1740-2522 |
ISSN (Online): | 1740-2530 |
Published Online: | 24 December 2012 |
Copyright Holders: | Copyright © 2012 David A. Leonard et al. |
First Published: | First published in Clinical and Developmental Immunology 2012: 863264 |
Publisher Policy: | Reproduced under a Creative Commons License |
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