Tolerance induction strategies in vascularized composite allotransplantation: mixed chimerism and novel developments.

Leonard, D. A. , McGrouther, D. A., Kurtz, J. M. and Cetrulo, C. L. (2012) Tolerance induction strategies in vascularized composite allotransplantation: mixed chimerism and novel developments. Clinical and Developmental Immunology, 2012, 863264. (doi: 10.1155/2012/863264) (PMID:23320020) (PMCID:PMC3540904)

[img]
Preview
Text
220841.pdf - Published Version
Available under License Creative Commons Attribution.

2MB

Abstract

Since the start of the clinical vascularized composite allotransplantation (VCA) era over a decade ago this field has witnessed significant developments in both basic and translational research. Transplant tolerance, defined as rejection-free acceptance of transplanted organs or tissues without long-term immunosuppression, holds the potential to revolutionize the field of VCA by removing the need for life-long immunosuppression. While tolerance of organ and vascularized composite transplants may be induced in small animal models by a variety of protocols, only mixed-chimerism-based protocols have successfully bridged the gap to preclinical study and to clinical trial in solid organ transplantation to date. In this paper we review the mixed-chimerism approach to tolerance induction, with specific reference to the field of VCA transplantation, and provide an overview of some novel cellular therapies as potential adjuvants to mixed chimerism in the development of tolerance induction protocols for clinical vascularized composite allotransplantation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Leonard, Dr David
Authors: Leonard, D. A., McGrouther, D. A., Kurtz, J. M., and Cetrulo, C. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Clinical and Developmental Immunology
Publisher:Hindawi
ISSN:1740-2522
ISSN (Online):1740-2530
Published Online:24 December 2012
Copyright Holders:Copyright © 2012 David A. Leonard et al.
First Published:First published in Clinical and Developmental Immunology 2012: 863264
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record