Kaller, M. S., Lazari, A., Blanco-Duque, C., Sampaio-Baptista, C. and Johansen-Berg, H. (2017) Myelin plasticity and behaviour — connecting the dots. Current Opinion in Neurobiology, 47, pp. 86-92. (doi: 10.1016/j.conb.2017.09.014) (PMID:29054040) (PMCID:PMC5844949)
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Abstract
Myelin sheaths in the vertebrate nervous system enable faster impulse propagation, while myelinating glia provide vital support to axons. Once considered a static insulator, converging evidence now suggests that myelin in the central nervous system can be dynamically regulated by neuronal activity and continues to participate in nervous system plasticity beyond development. While the link between experience and myelination gains increased recognition, it is still unclear what role such adaptive myelination plays in facilitating and shaping behaviour. Additionally, fundamental mechanisms and principles underlying myelin remodelling remain poorly understood. In this review, we will discuss new insights into the link between myelin plasticity and behaviour, as well as mechanistic aspects of myelin remodelling that may help to elucidate this intriguing process.
Item Type: | Articles |
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Additional Information: | MSK, AL and CDB are funded by PhD Studentships from the Wellcome Trust (Grant Numbers: 102393/Z/13/Z, 109062/Z/15/Z and 109059/Z/15/Z). HJB is funded by a Principal Research Fellowship from the Wellcome Trust (110027/Z/15/Z). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Sampaio Baptista, Dr Cassandra |
Authors: | Kaller, M. S., Lazari, A., Blanco-Duque, C., Sampaio-Baptista, C., and Johansen-Berg, H. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Current Opinion in Neurobiology |
Publisher: | Elsevier |
ISSN: | 0959-4388 |
ISSN (Online): | 1873-6882 |
Published Online: | 17 October 2017 |
Copyright Holders: | Copyright © 2017 The Authors |
First Published: | First published in Current Opinion in Neurobiology 47: 86-92 |
Publisher Policy: | Reproduced under a Creative Commons License |
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