Myelin plasticity and behaviour — connecting the dots

Kaller, M. S., Lazari, A., Blanco-Duque, C., Sampaio-Baptista, C. and Johansen-Berg, H. (2017) Myelin plasticity and behaviour — connecting the dots. Current Opinion in Neurobiology, 47, pp. 86-92. (doi: 10.1016/j.conb.2017.09.014) (PMID:29054040) (PMCID:PMC5844949)

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Abstract

Myelin sheaths in the vertebrate nervous system enable faster impulse propagation, while myelinating glia provide vital support to axons. Once considered a static insulator, converging evidence now suggests that myelin in the central nervous system can be dynamically regulated by neuronal activity and continues to participate in nervous system plasticity beyond development. While the link between experience and myelination gains increased recognition, it is still unclear what role such adaptive myelination plays in facilitating and shaping behaviour. Additionally, fundamental mechanisms and principles underlying myelin remodelling remain poorly understood. In this review, we will discuss new insights into the link between myelin plasticity and behaviour, as well as mechanistic aspects of myelin remodelling that may help to elucidate this intriguing process.

Item Type:Articles
Additional Information:MSK, AL and CDB are funded by PhD Studentships from the Wellcome Trust (Grant Numbers: 102393/Z/13/Z, 109062/Z/15/Z and 109059/Z/15/Z). HJB is funded by a Principal Research Fellowship from the Wellcome Trust (110027/Z/15/Z).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sampaio Baptista, Dr Cassandra
Authors: Kaller, M. S., Lazari, A., Blanco-Duque, C., Sampaio-Baptista, C., and Johansen-Berg, H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Current Opinion in Neurobiology
Publisher:Elsevier
ISSN:0959-4388
ISSN (Online):1873-6882
Published Online:17 October 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Current Opinion in Neurobiology 47: 86-92
Publisher Policy:Reproduced under a Creative Commons License

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