Changes in white matter microstructure in the developing brain—a longitudinal diffusion tensor imaging study of children from 4 to 11 years of age

Krogsrud, S. K. et al. (2016) Changes in white matter microstructure in the developing brain—a longitudinal diffusion tensor imaging study of children from 4 to 11 years of age. NeuroImage, 124(Part A), pp. 473-486. (doi: 10.1016/j.neuroimage.2015.09.017) (PMID:26375208) (PMCID:PMC4655940)

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Abstract

The purpose of the present study was to detail the childhood developmental course of different white matter (WM) characteristics. In a longitudinal diffusion tensor imaging (DTI) study of 159 healthy children between 4 and 11 years scanned twice, we used tract-based spatial statistics as well as delineation of 15 major WM tracts to characterize the regional pattern of change in fractional anisotropy (FA), mean (MD), radial (RD) and axial diffusivity (AD). We tested whether there were decelerations of change with increasing age globally and tract-wise, and also illustrated change along medial-to-lateral, posterior-to-anterior and inferior-to-superior gradients. We found a significant linear increase in global FA, and decrease in MD and RD over time. For mean AD, a weak decrease was observed. The developmental changes in specific WM tracts showed regional differences. Eight WM tracts showed non-linear development patterns for one or several DTI metrics, with a deceleration in change with age. Sex did not affect change in any DTI metric. Overall, greater rate of change was found in the left hemisphere. Spatially, there was a posterior-to-anterior gradient of change with greater change in frontal regions for all metrics. The current study provides a comprehensive characterization of the regional patters of change in WM microstructure across pre-adolescence childhood.

Item Type:Articles
Additional Information:The study was financed by the Norwegian Research Council (204935) (C.K.T., A.M.F., K.B.W.), the European Research Council (313440) (A.M.F., K.B.W.), and the Department of Psychology, University of Oslo (283634) (C.K.T., A.M.F., K.B.W.). H.J-B and C.S-B are supported by the Wellcome Trust (WT090955AIA).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sampaio Baptista, Dr Cassandra
Authors: Krogsrud, S. K., Fjell, A. M., Tamnes, C. K., Grydeland, H., Mork, L., Due-Tønnessen, P., Bjørnerud, A., Sampaio-Baptista, C., Andersson, J., Johansen-Berg, H., and Walhovd, K. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:NeuroImage
Publisher:Elsevier
ISSN:1053-8119
ISSN (Online):1095-9572
Published Online:12 September 2015
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in NeuroImage 124(Part A): 473-486
Publisher Policy:Reproduced under a Creative Commons License

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