Kingham, P. J., Birchall, M. A., Murison, P. , Burt, R., Jones, A. and Terenghi, G. (2005) Reinnervation of laryngeal muscles: A study of changes in myosin heavy chain expression. Muscle and Nerve, 32(6), pp. 761-766. (doi: 10.1002/mus.20409) (PMID:16007678)
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Abstract
Direct repair of the recurrent laryngeal nerve (RLN) results in synkinesis and compromised laryngeal function. We have therefore developed a pig model to investigate whether anastomosis of the phrenic nerve with the abductor branch of the RLN leads to specific reinnervation of abductor muscles. Expression of myosin heavy chain protein (MyHC), a marker of appropriate reinnervation, was determined in the posterior cricoarytenoid (PCA) abductor and thyroarytenoid (TA) adductor muscles following nerve injury and repair. The denervated PCA muscle exhibited decreased levels of the fast-type MyHC isoforms IIA and IIB, and increased slow-type MyHC expression. Similarly, there was a fall in type IIB levels in the denervated TA muscle but increases in both IIA and slow MyHC. Four months after repair, the MyHC expression in the PCA was near normal, suggesting that our model reduces the risk of synkinesis and ensures the accurate muscle reinnervation required for full functional recovery.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Murison, Professor Pamela |
| Authors: | Kingham, P. J., Birchall, M. A., Murison, P., Burt, R., Jones, A., and Terenghi, G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Muscle and Nerve |
| Publisher: | Wiley |
| ISSN: | 0148-639X |
| ISSN (Online): | 1097-4598 |
| Published Online: | 08 July 2005 |
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