Biomarkers profile of people with sarcopenia: a cross-sectional analysis from UK Biobank

Petermann-Rocha, F., Gray, S. R. , Pell, J. P. , Celis-Morales, C. and Ho, F. K. (2020) Biomarkers profile of people with sarcopenia: a cross-sectional analysis from UK Biobank. Journal of the American Medical Directors Association, (doi: 10.1016/j.jamda.2020.05.005) (Early Online Publication)

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Abstract

Objective: This study aimed to characterize the biomarker profile of sarcopenic vs nonsarcopenic men and women, using the current European Working Group on Sarcopenia in Older People (EWGSOP2) definition in the UK Biobank study. Design: Cross-sectional study. Setting and Participants: A total of 396,707 (68.8% women, age 38 to 73) participants from UK Biobank. Measures: Thirty-three biomarkers, standardized to sex-specific z-scores, were included in the analysis. Associations between these biomarkers and sarcopenia, defined using EWGSOP2 criteria, were examined using multiple linear regression. Results: Higher concentrations of rheumatoid factor, C-reactive protein, cystatin C, sex hormone-binding globulin, gamma-glutamyltransferase, alkaline phosphatase, and total protein, as well as lower concentrations of insulin-like growth factor-1, albumin, creatinine, sodium, and systolic blood pressure, were associated with sarcopenia in both men and women. However, some of the associations differed by sex. Sarcopenia was associated with higher concentrations of phosphate, lipoprotein A, and lower of diastolic blood pressure, HbA1c, urea, glucose, total bilirubin, and testosterone in women only, and with higher concentrations of high-density lipoprotein, aspartate aminotransferase, and direct bilirubin and lower values of apolipoprotein A, vitamin D, and apolipoprotein B in men only. Conclusions and Implications: Several biomarkers were associated with sarcopenia in men and women using the new EWGSOP2 statement. However, some of these associations and their magnitude differed between men and women. Considering the EWGSOP2 updated its statement on the definition of sarcopenia in 2019, this study enables us to update the study of the biomarkers profile of people with sarcopenia.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ho, Dr Frederick and Celis, Dr Carlos and Gray, Dr Stuart and Petermann Rocha, Fanny and Pell, Professor Jill
Authors: Petermann-Rocha, F., Gray, S. R., Pell, J. P., Celis-Morales, C., and Ho, F. K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:Journal of the American Medical Directors Association
Publisher:Elsevier
ISSN:1525-8610
ISSN (Online):1538-9375
Published Online:05 July 2020

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