Birchall, M. A. et al. (2011) Laryngeal transplantation in minipigs: vascular, myologic and functional outcomes. European Archives of Oto-Rhino-Laryngology, 268(3), pp. 405-414. (doi: 10.1007/s00405-010-1355-3) (PMID:20842506) (PMCID:PMC3192951)
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Abstract
There is no effective way of replacing all the functions of the larynx in those requiring laryngectomy. Regenerative medicine offers promise, but cannot presently deliver implants with functioning neuromuscular units. A single well-documented laryngeal transplant in man was a qualified success, but more information is required before clinical trials may be proposed. We studied the early response of the larynx to laryngeal transplantation between 17 pairs of NIH minipigs full matched at the MHC2 locus. Following iterative technical improvements, pigs had good swallowing and a patent airway at 1 week. No significant changes in mucosal blood flux were observed compared with pre-operative measurements. Changes in muscle morphology and fibre phenotype were observed in transplant muscles retrieved after 7 days: the levels of fast and slow myosin heavy chain (MyHC) protein were reduced and embryonic MyHC was up regulated consistent with denervation induced atrophy. At 1 week laryngeal transplantation can result in good swallowing, and is not associated with clinical evidence of ischemia-reperfusion injury in MHC-matched pigs.
| Item Type: | Articles |
|---|---|
| Additional Information: | A correction to this article is available at https://doi.org/10.1007/s00405-016-4357-y. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Murison, Professor Pamela |
| Authors: | Birchall, M. A., Kingham, P. J., Murison, P.J., Ayling, S. M., Burt, R., Mitchard, L., Jones, A., Lear, P., Stokes, C. R., Terenghi, G., Bailey, M., and Macchiarini, P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | European Archives of Oto-Rhino-Laryngology |
| Publisher: | Springer on behalf of European Federation of Oto-Rhino-Laryngological Societies and European Laryngological Society |
| ISSN: | 0937-4477 |
| ISSN (Online): | 1434-4726 |
| Published Online: | 15 September 2010 |
| Copyright Holders: | Copyright © 2010 Springer-Verlag |
| First Published: | First published in European Archives of Oto-Rhino-Laryngology 268(3):405-414 |
| Publisher Policy: | Reproduced under a Creative Commons License |
| Related URLs: |
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