Bachmann, B., Taylor, R. S. and Cursiefen, C. (2013) The association between corneal neovascularization and visual acuity : a systematic review. Acta Ophthalmologica, 91(1), pp. 12-19. (doi: 10.1111/j.1755-3768.2011.02312.x) (PMID:22103683)
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Abstract
Purpose: Corneal neovascularization (CNV) is thought to negatively influence visual acuity. New therapeutic options that offer a differentiated influence on the ingrowths or regression of either corneal blood or lymphatic vessels force us to re-evaluate the association between CNV and visual acuity. Methods: A systematic review was conducted. Electronic databases were searched up to August 2009. Given the heterogeneity in study populations, interventions and measures of association, we were unable to undertake meta-analysis. The association between CNV and visual acuity was reported descriptively for each study. Results: Eleven studies using either vascular endothelial growth factor inhibitor treatments (i.e. bevacizumab, Avastin(®) ; Hoffmann-La Roche AG, Basel, Switzerland) or an antiangiogenic treatment based on IRS-1 modulation [Gene-Signal (GS) 101, Aganirsen(®) ; GeneSignal, Evry (Paris), France] in a total of 131 patients (142 eyes) with corneal neovascularization were included. Ten of the eleven studies reported evidence of a statistically significant reduction in neovascularization following treatment. However, only four studies reported a statistically significant improvement in visual acuity following therapy. We found no studies that assessed the patient-level association between the change in neovascularization and visual acuity. Conclusion: This systematic review found that there is currently weak evidence to support the hypothesis that in patients with pathological neovascularization, a treatment-related reduction in neovascularization is associated with an increase in visual acuity. There is a need for future appropriately designed studies.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Taylor, Professor Rod |
| Authors: | Bachmann, B., Taylor, R. S., and Cursiefen, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU |
| Journal Name: | Acta Ophthalmologica |
| Publisher: | Nordic Ophthalmological Societies |
| ISSN: | 1755-375X |
| ISSN (Online): | 1755-3768 |
| Published Online: | 22 November 2011 |
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