White matter plasticity in the adult brain

Sampaio-Baptista, C. and Johansen-Berg, H. (2017) White matter plasticity in the adult brain. Neuron, 96(6), pp. 1239-1251. (doi: 10.1016/j.neuron.2017.11.026) (PMID:29268094) (PMCID:PMC5766826)

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The study of brain plasticity has tended to focus on the synapse, where well-described activity-dependent mechanisms are known to play a key role in learning and memory. However, it is becoming increasingly clear that plasticity occurs beyond the synapse. This review focuses on the emerging concept of white matter plasticity. For example, there is growing evidence, both from animal studies and from human neuroimaging, that activity-dependent regulation of myelin may play a role in learning. This previously overlooked phenomenon may provide a complementary but powerful route through which experience shapes the brain.

Item Type:Articles
Additional Information:This work was supported by the Wellcome Trust. H.J.-B. is funded by a Wellcome Trust Principal Research Fellowship (110027/Z/15/Z).
Glasgow Author(s) Enlighten ID:Sampaio Baptista, Dr Cassandra
Authors: Sampaio-Baptista, C., and Johansen-Berg, H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Neuron
Publisher:Elsevier (Cell Press)
ISSN (Online):1097-4199
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Neuron 96(6): 1239-1251
Publisher Policy:Reproduced under a Creative Commons License

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