Structural plasticity in adulthood with motor learning and stroke rehabilitation

Sampaio-Baptista, C. , Sanders, Z.-B. and Johansen-Berg, H. (2018) Structural plasticity in adulthood with motor learning and stroke rehabilitation. Annual Review of Neuroscience, 41, pp. 25-40. (doi: 10.1146/annurev-neuro-080317-062015) (PMID:29490196)

Full text not currently available from Enlighten.


The development of advanced noninvasive techniques to image the human brain has enabled the demonstration of structural plasticity during adulthood in response to motor learning. Understanding the basic mechanisms of structural plasticity in the context of motor learning is essential to improve motor rehabilitation in stroke patients. Here, we review and discuss the emerging evidence for motor-learning-related structural plasticity and the implications for stroke rehabilitation. In the clinical context, a few studies have started to assess the effects of rehabilitation on structural measures to understand recovery poststroke and additionally to predict intervention outcomes. Structural imaging will likely have a role in the future in providing measures that inform patient stratification for optimal outcomes.

Item Type:Articles
Additional Information:This work was supported by the Wellcome Trust. H.J.-B. is funded by a Principal Research Fellowship from the Wellcome Trust (110027/Z/15/Z). Z.-B.S. is funded by the Clarendon Fund and Nuffield Department of Clinical Neuroscience Studentship, University of Oxford.
Glasgow Author(s) Enlighten ID:Sampaio Baptista, Dr Cassandra
Authors: Sampaio-Baptista, C., Sanders, Z.-B., and Johansen-Berg, H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Annual Review of Neuroscience
Publisher:Annual Reviews
ISSN (Online):1545-4126
Published Online:28 February 2018

University Staff: Request a correction | Enlighten Editors: Update this record