Experience-related reductions of myelin and axon diameter in adulthood

Lazari, A., Koudelka, S. and Sampaio-Baptista, C. (2018) Experience-related reductions of myelin and axon diameter in adulthood. Journal of Neurophysiology, 120(4), pp. 1772-1775. (doi: 10.1152/jn.00070.2018) (PMID:30207857) (PMCID:PMC6230794)

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The production of new myelin has been highlighted as an underappreciated mechanism of brain plasticity, but whether plastic decreases in myelin also happen in the adult brain has been largely unexplored. Recently, Sinclair et al. (Sinclair JS, Fischl MJ, Alexandrova O, Heß M, Grothe B, Leibold C, and Kopp-Scheinpflug C. J Neurosci 37: 8239–8255, 2017) have shown that auditory deprivation can lead to decrease in myelination and axon caliber even in healthy adulthood. These findings show that activity-regulated myelination is more complex than previously thought and expand our knowledge of how adult brain plasticity could operate on a cellular level.

Item Type:Articles
Additional Information:A. Lazari is funded by a PhD Studentship from the Wellcome Trust (grant number 109062/Z/15/Z).
Glasgow Author(s) Enlighten ID:Sampaio Baptista, Dr Cassandra
Authors: Lazari, A., Koudelka, S., and Sampaio-Baptista, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Journal of Neurophysiology
Publisher:American Physiological Society
ISSN (Online):1522-1598
Published Online:05 October 2018
Copyright Holders:Copyright © 2018 American Physiological Society
First Published:First published in Journal of Neurophysiology 120(4): 1772-1775
Publisher Policy:Reproduced under a Creative Commons License

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