Lazari, A., Koudelka, S. and Sampaio-Baptista, C. (2018) Experience-related reductions of myelin and axon diameter in adulthood. Journal of Neurophysiology, 120(4), pp. 1772-1775. (doi: 10.1152/jn.00070.2018) (PMID:30207857) (PMCID:PMC6230794)
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Abstract
The production of new myelin has been highlighted as an underappreciated mechanism of brain plasticity, but whether plastic decreases in myelin also happen in the adult brain has been largely unexplored. Recently, Sinclair et al. (Sinclair JS, Fischl MJ, Alexandrova O, Heß M, Grothe B, Leibold C, and Kopp-Scheinpflug C. J Neurosci 37: 8239–8255, 2017) have shown that auditory deprivation can lead to decrease in myelination and axon caliber even in healthy adulthood. These findings show that activity-regulated myelination is more complex than previously thought and expand our knowledge of how adult brain plasticity could operate on a cellular level.
Item Type: | Articles |
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Additional Information: | A. Lazari is funded by a PhD Studentship from the Wellcome Trust (grant number 109062/Z/15/Z). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Sampaio Baptista, Dr Cassandra |
Authors: | Lazari, A., Koudelka, S., and Sampaio-Baptista, C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Journal of Neurophysiology |
Publisher: | American Physiological Society |
ISSN: | 0022-3077 |
ISSN (Online): | 1522-1598 |
Published Online: | 05 October 2018 |
Copyright Holders: | Copyright © 2018 American Physiological Society |
First Published: | First published in Journal of Neurophysiology 120(4): 1772-1775 |
Publisher Policy: | Reproduced under a Creative Commons License |
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