Magnetic resonance techniques for imaging white matter

Sampaio-Baptista, C. , Diosi, K. and Johnansen-Berg, H. (2019) Magnetic resonance techniques for imaging white matter. In: Lyons, D. A. and Kegel, L. (eds.) Oligodendrocytes: Methods and Protocols. Series: Methods in molecular biology (1936). Humana Press: New York, NY, pp. 397-407. ISBN 9781493990702 (doi:10.1007/978-1-4939-9072-6_22)

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The white matter is a complex network of brain fibers connecting different information processing regions in the brain. In recent years, the investigation of white matter in humans and in animal models has greatly benefitted from the introduction of in vivo noninvasive magnetic resonance imaging (MRI) techniques. MRI allows for multiple in vivo time-point whole-brain acquisition in the same subject, thus it can be used longitudinally to monitor white matter brain change, intervention effects, as well as disease progression. However, MRI has low spatial resolution compared to gold standard cellular techniques and MRI measures are sensitive to a number of tissue properties resulting in a lack of specificity. The following chapter describes in simple technical terms to non-imaging experts some common MRI techniques that can be used to investigate white matter structure noninvasively, covering some of the advantages and pitfalls of each technique.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Sampaio Baptista, Dr Cassandra
Authors: Sampaio-Baptista, C., Diosi, K., and Johnansen-Berg, H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Publisher:Humana Press

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