Advances in noninvasive myelin imaging

Heath, F., Hurley, S. A., Johansen-Berg, H. and Sampaio-Baptista, C. (2018) Advances in noninvasive myelin imaging. Developmental Neurobiology, 78(2), pp. 136-151. (doi: 10.1002/dneu.22552) (PMID:29082667) (PMCID:PMC5813152)

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Abstract

Myelin is important for the normal development and healthy function of the nervous system. Recent developments in MRI acquisition and tissue modeling aim to provide a better characterization and more specific markers for myelin. This allows for specific monitoring of myelination longitudinally and noninvasively in the healthy brain as well as assessment of treatment and intervention efficacy. Here, we offer a nontechnical review of MRI techniques developed to specifically monitor myelin such as magnetization transfer (MT) and myelin water imaging (MWI). We further summarize recent studies that employ these methods to measure myelin in relation to development and aging, learning and experience, and neuropathology and psychiatric disorders.

Item Type:Articles
Additional Information:This work was supported by Wellcome Principal Research Fellowship to HJB (WT110027/Z/15/Z).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sampaio Baptista, Dr Cassandra
Authors: Heath, F., Hurley, S. A., Johansen-Berg, H., and Sampaio-Baptista, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Developmental Neurobiology
Publisher:Wiley
ISSN:1932-8451
ISSN (Online):1932-846X
Published Online:30 October 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Developmental Neurobiology 78(2): 136-151
Publisher Policy:Reproduced under a Creative Commons License

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