Application of healthcare 'big data' in CNS drug research: the example of the Neurological and mental health Global Epidemiology Network (NeuroGEN)

Ilomäki, J. et al. (2020) Application of healthcare 'big data' in CNS drug research: the example of the Neurological and mental health Global Epidemiology Network (NeuroGEN). CNS Drugs, 34(9), pp. 897-913. (doi: 10.1007/s40263-020-00742-4) (PMID:32572794) (PMCID:PMC7306570)

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Abstract

Neurological and psychiatric (mental health) disorders have a large impact on health burden globally. Cognitive disorders (including dementia) and stroke are leading causes of disability. Mental health disorders, including depression, contribute up to one-third of total years lived with disability. The Neurological and mental health Global Epidemiology Network (NeuroGEN) is an international multi-database network that harnesses administrative and electronic medical records from Australia, Asia, Europe and North America. Using these databases NeuroGEN will investigate medication use and health outcomes in neurological and mental health disorders. A key objective of NeuroGEN is to facilitate high-quality observational studies to address evidence-practice gaps where randomized controlled trials do not provide sufficient information on medication benefits and risks that is specific to vulnerable population groups. International multi-database research facilitates comparisons across geographical areas and jurisdictions, increases statistical power to investigate small subpopulations or rare outcomes, permits early post-approval assessment of safety and effectiveness, and increases generalisability of results. Through bringing together international researchers in pharmacoepidemiology, NeuroGEN has the potential to be paradigm-changing for observational research to inform evidence-based prescribing. The first focus of NeuroGEN will be to address evidence-gaps in the treatment of chronic comorbidities in people with dementia.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Pell, Professor Jill and Ho, Dr Frederick
Authors: Ilomäki, J., Bell, J. S., Chan, A. Y. L., Tolppanen, A.-M., Luo, H., Wei, L., Lai, E. C.-C., Shin, J.-Y., De Paoli, G., Pajouheshnia, R., Ho, F. K., Reynolds, L., Lau, K. K., Crystal, S., Lau, W. C. Y., Man, K. K. C., Brauer, R., Chan, E. W., Shen, C.-Y., Kim, J. H., Lum, T. Y. S., Hartikainen, S., Koponen, M., Rooke, E., Bazelier, M., Klungel, O., Setoguchi, S., Pell, J. P., Cook, S., and Wong, I. C. K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:CNS Drugs
Publisher:Springer
ISSN:1172-7047
ISSN (Online):1179-1934
Published Online:22 June 2020
Copyright Holders:Copyright © 2020 Springer Nature Switzerland AG
First Published:First published in CNS Drugs 34(9): 897-913
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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