The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study

Mangion, K. et al. (2020) The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study. Cardiovascular Research, 116(14), pp. 2185-2196. (doi: 10.1093/cvr/cvaa209) (PMID:32702087) (PMCID:PMC7454350)

Abstract

Background: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. Methods: This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation. Conclusion: CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients.

• Item Type: Articles
• Keywords: SARS-CoV-2, myocardial inflammation, myocardial infarction, myocardial injury, imaging, biomarkers.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Macfarlane, Professor Peter and McConnachie, Professor Alex and Gillespie, Dr Lynsey and Kean, Ms Sharon and Ho, Dr Antonia and Corcoran, Dr David and Mangion, Dr Kenneth and Lowe, Dr David and Bagot, Dr Catherine and Morrow, Dr Andrew and Touyz, Professor Rhian and Berry, Professor Colin and Delles, Professor Christian and Wright, Dr Sylvia and Blyth, Professor Kevin and Lang, Professor Ninian and Roditi, Dr Giles and Wereski, Dr Ryan and Sattar, Professor Naveed and Sykes, Dr Robert and Bayes, Dr Hannah
• Authors: Mangion, K., Morrow, A., Bagot, C., Bayes, H., Blyth, K. G., Church, C., Corcoran, D., Delles, C., Gillespie, L., Grieve, D., Ho, A., Kean, S., Lang, N. N., Lennie, V., Lowe, D., Kellman, P., Macfarlane, P. W., McConnachie, A., Roditi, G., Sykes, R., Touyz, R. M., Sattar, N., Wereski, R., Wright, S., and Berry, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre; College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Cardiovascular Research
• Publisher: Oxford University Press
• ISSN: 0008-6363
• ISSN (Online): 1755-3245
• Published Online: 23 July 2020
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in Cardiovascular Research 116(14):2185–2196
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
311300		CSO covid 19 portfolio	Iain McInnes	Chief Scientist Office (CSO)	COV/GLA/Portfolio	III - Immunology