Sarrigiannidis, S. O., Moussa, H., Dobre, O. , Dalby, M. J. , Tamimi, F. and Salmerón-Sánchez, M. (2020) Chiral tartaric acid improves fracture toughness of bioactive brushite-collagen bone cements. ACS Applied Bio Materials, 3(8), pp. 5056-5066. (doi: 10.1021/acsabm.0c00555) (PMID:32904797) (PMCID:PMC7461128)
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Abstract
Brushite cements are promising bone regeneration materials with limited biological and mechanical properties. Here, we engineer a mechanically improved brushite-collagen type I cement with enhanced biological properties by use of chiral chemistry; D- and L-tartaric acid were used to limit crystal growth and increase the mechanical properties of brushite-collagen cements. The impact of the chiral molecules on the cements was examined with FTIR, XRD and SEM. A 3-point bend test was utilised to study the fracture toughness and cell attachment and morphology studies to demonstrate biocompatibility. XRD and SEM analyses showed that L- but not D- tartaric acid, significantly restrained brushite crystal growth by binding to the {010} plane of the mineral, increased brushite crystal packing and the collagen-mineral interaction area. L-tartaric acid significantly improved fracture toughness compared to traditional brushite by 30 %. Collagen significantly enhanced cell morphology and focal adhesion expression on brushite cements.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Salmeron-Sanchez, Professor Manuel and Dobre, Dr Oana and Sarrigiannidis, Stylianos and Dalby, Professor Matthew |
| Authors: | Sarrigiannidis, S. O., Moussa, H., Dobre, O., Dalby, M. J., Tamimi, F., and Salmerón-Sánchez, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Engineering College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | ACS Applied Bio Materials |
| Publisher: | American Chemical Society |
| ISSN: | 2576-6422 |
| ISSN (Online): | 2576-6422 |
| Published Online: | 06 July 2020 |
| Copyright Holders: | Copyright © 2020 American Chemical Society |
| First Published: | First published in ACS Applied Bio Materials 3(8):5056–5066 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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