Chiral tartaric acid improves fracture toughness of bioactive brushite-collagen bone cements

Sarrigiannidis, S. O. , Moussa, H. , Dobre, O. , Dalby, M. J. , Tamimi, F. and Salmerón-Sánchez, M. (2020) Chiral tartaric acid improves fracture toughness of bioactive brushite-collagen bone cements. ACS Applied Bio Materials, 3(8), pp. 5056-5066. (doi: 10.1021/acsabm.0c00555) (PMID:32904797) (PMCID:PMC7461128)

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Abstract

Brushite cements are promising bone regeneration materials with limited biological and mechanical properties. Here, we engineer a mechanically improved brushite-collagen type I cement with enhanced biological properties by use of chiral chemistry; D- and L-tartaric acid were used to limit crystal growth and increase the mechanical properties of brushite-collagen cements. The impact of the chiral molecules on the cements was examined with FTIR, XRD and SEM. A 3-point bend test was utilised to study the fracture toughness and cell attachment and morphology studies to demonstrate biocompatibility. XRD and SEM analyses showed that L- but not D- tartaric acid, significantly restrained brushite crystal growth by binding to the {010} plane of the mineral, increased brushite crystal packing and the collagen-mineral interaction area. L-tartaric acid significantly improved fracture toughness compared to traditional brushite by 30 %. Collagen significantly enhanced cell morphology and focal adhesion expression on brushite cements.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and Sarrigiannidis, Mr Stylianos and Dobre, Dr Oana and Dalby, Professor Matthew
Authors: Sarrigiannidis, S. O., Moussa, H., Dobre, O., Dalby, M. J., Tamimi, F., and Salmerón-Sánchez, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:ACS Applied Bio Materials
Publisher:American Chemical Society
ISSN:2576-6422
ISSN (Online):2576-6422
Published Online:06 July 2020
Copyright Holders:Copyright © 2020 American Chemical Society
First Published:First published in ACS Applied Bio Materials 3(8):5056–5066
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173192Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicineManuel Salmeron-SanchezEngineering and Physical Sciences Research Council (EPSRC)EP/P001114/1ENG - Biomedical Engineering
301095UKRMP2 Acellular/Smart Materials 3D Architecture HubManuel Salmeron-SanchezMedical Research Council (MRC)MR/R015651/1ENG - Biomedical Engineering