The systemic inflammatory response following hand instrumentation vs ultrasonic instrumentation - a randomised controlled trial

Johnston, W., Paterson, M., Piela, K. M., Davison, E., Simpson, A., Goulding, M., Ramage, G. , Sherriff, A. and Culshaw, S. (2020) The systemic inflammatory response following hand instrumentation vs ultrasonic instrumentation - a randomised controlled trial. Journal of Clinical Periodontology, (doi: 10.1111/jcpe.13342) (PMID:32628781) (PMCID:32628781) (Early Online Publication)

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Abstract

Objective: This study sought to investigate whether the immediate systemic inflammatory response following full mouth debridement differs following use of hand compared with ultrasonic instruments. Methods: Thirty‐nine periodontitis patients were randomised to treatment with full‐mouth debridement using either hand or ultrasonic instrumentation completed within 24 hours. Serum and periodontal clinical parameters were collected at baseline, day 1, day 7 and day 90 post‐treatment. Differences in systemic inflammatory markers were assessed using general linear models at each time‐point, corrected for age, gender, smoking status, body mass index and baseline levels of each marker. Results: Across all patients, serum C‐reactive protein increased at day 1, with no differences between hand and ultrasonic groups (p(adjusted)=0.22). There was no difference between groups in interleukin‐6 (p(adjusted)=0.29) or tumour necrosis factor α (p(adjusted)=0.53) at day 1. Inflammatory markers returned to baseline levels by day 7. Treatment resulted in equal and marked improvements in clinical parameters in both groups; however, total treatment time was on average shorter for ultrasonic instruments (p(adjusted)=0.002). Conclusions: Ultrasonic instrumentation resulted in shorter treatment time with comparable clinical outcomes. Levels of serum C‐reactive protein at day 1 were similar following debridement with hand or ultrasonic instruments.

Item Type:Articles
Additional Information:The current study was jointly funded by the University of Glasgow’s PhD programme and Dentsply Sirona.
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sherriff, Dr Andrea and Ramage, Professor Gordon and Paterson, Mr Michael and Johnston, William and Culshaw, Professor Shauna
Authors: Johnston, W., Paterson, M., Piela, K. M., Davison, E., Simpson, A., Goulding, M., Ramage, G., Sherriff, A., and Culshaw, S.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
College of Medical Veterinary and Life Sciences
Journal Name:Journal of Clinical Periodontology
Publisher:Wiley
ISSN:0303-6979
ISSN (Online):1600-051X
Published Online:06 July 2020
Copyright Holders:Copyright © 2020 Wiley
First Published:First published in Journal of Clinical Periodontology 2020
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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