Genetic predisposition to coronary artery disease in type 2 diabetes

van Zuydam, N. R. et al. (2020) Genetic predisposition to coronary artery disease in type 2 diabetes. Circulation: Genomic and Precision Medicine, 13(6), e002769. (doi: 10.1161/CIRCGEN.119.002769) (PMID:33321069) (PMCID:PMC7748049)

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Abstract

Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes (T2D). Methods: To test whether this reflects differential genetic influences on CAD-risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66,643 subjects (27,708 with CAD and 24,259 with T2D). Variants showing apparent association with CAD in stratified analyses and/or evidence of interaction were evaluated in a further 117,787 subjects (16,694 with CAD and 11,537 with T2D). Results: None of the previously characterised CAD loci was found to have specific effects on CAD in T2D individuals and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. Conclusions: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared to those without T2D.

Item Type:Articles
Additional Information:This work was supported by the European Union Framework Programme 7 (FP7/2007-2013) for the Innovative Medicine Initiative (IMI) under grant agreement n° IMI/115006 (the SUMMIT consortium); Aarno Koskelo Foundation; Academy of Finland (#263401; #2676882); American Heart Association (13SDG14330006); AstraZeneca; AtheroSysMed (Systems medicine of coronary heart disease and stroke); British Heart Foundation Centre of Research Excellence at Oxford; ERC269045-Gene Target T2D grant; Estonian Research Council (IUT20-60, PUT1660 and PUT1665P); Estonian Center of Genomics/Roadmap II (project No. 2014-2020.4.01.16-0125); European Union (#692145; #633589; #313010; LSHM-CT-2007-037273; #201668; 2014-2020.4.01.15-0012;QLG1-CT-2002-00896; EU/QLRT-2001-01254; QLG2-CT-2002-01254 HEALTH-F2-2013-601456); Finnish Foundation for Cardiovascular research; Gentransmed - Centre of Excellence for Genomics and Translational Medicine; German Ministry of Education and Research (#01ZX1313A-K); Helsinki University Central Hospital special government funds (EVO #TYH7215, #TKK2012005, #TYH2012209, #TYH2014312); Juvenile Diabetes Research Foundation (JDRF, 2-SRA-2014-276-Q-R); National Institute of Diabetes and Digestive and Kidney diseases (NIDDK, 5R01DK106236; U01-DK066134; U01-DK105535; R01DK101478); National Heart, Lung and Blood Institute (NLHBI, R01HL103866); National Institute for Health Research (NIHR); RiskyCAD (305739); Sigrid Juselius Foundation; Finnish Academy (#269517); Finnish Foundation for Cardiovascular Research; Foundation for Strategic Research and Stockholm County Council (560283; 592229); Juho Vainio Foundation; Knut and Alice Wallenberg Foundation; Ministry for Higher Education; Strategic Cardiovascular and Diabetes Programmes of Karolinska Institutet and Stockholm County Council; Swedish Foundation for Strategic Research (SSF; ICA08-0047); Swedish Heart-Lung Foundation; Swedish Research Council (project 8691; 2015-02558; 2016-00598; M-2005-1112 and 2009-2298); Torsten and Ragnar Söderberg Foundation; W.W. Smith Charitable Trust (H1201); Wellcome Trust institutional strategic support fund; Yrjö Jahnsson Foundation.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Strawbridge, Dr Rona
Authors: van Zuydam, N. R., Ladenvall, C., Voight, B. F., Strawbridge, R. J., Tajes, J. F., Rayner, N. W., Robertson, N. R., Mahajan, A., Vlachopoulou, E., Goel, A., Kleber, M. E., Nelson, C. P., Coulter Kwee, L., Esko, T., Mihailov, E., Mägi, R., Milani, L., Fischer, K., Kanoni, S., Kumar, J., Song, C., Hartiala, J. A., Pedersen, N. L., Perola, M., Gieger, C., Peters, A., Qu, L., Willems, S. M., Doney, A. S.F., Morris, A. D., Zheng, Y., Sesti, G., Hu, F. B., Qi, L., Laakso, M., Thorsteinsdottir, U., Grallert, H., van Duijn, C., Reilly, M. P., Ingelsson, E., Deloukas, P., Kathiresan, S., Metspalu, A., Shah, S. H., Samani, N. J., Maerz, W., Hazen, S. L., Watkins, H., Saleheen, D., SUMMIT Steering Committee, , CARDIOGRAMplusC4D Steering Committee, , Morris, A. P., Colhoun, H. M., Groop, L., McCarthy, M. I., and Palmer, C. N.A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Circulation: Genomic and Precision Medicine
Publisher:American Heart Association
ISSN:2574-8300
ISSN (Online):2574-8300
Published Online:13 August 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Circulation: Genomic and Precision Medicine 13(6):e002769
Publisher Policy:Reproduced under a Creative Commons License

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