Isotopic control over self-assembly in supramolecular gels

McAulay, K., Wang, H., Fuentes-Caparrós, A. M., Thomson, L., Khunti, N., Cowieson, N., Cui, H., Seddon, A. and Adams, D. J. (2020) Isotopic control over self-assembly in supramolecular gels. Langmuir, 36(29), pp. 8626-8631. (doi: 10.1021/acs.langmuir.0c01552) (PMID:32614592) (PMCID:PMC7467762)

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Abstract

It is common to switch between H2O and D2O when examining peptide-based systems with the assumption being that there are no effects from this change. Here, we describe the effect of changing from H2O to D2O in a number of low molecular weight dipeptide-based gels. Gels are formed by decreasing the pH. In most cases, there is little dif-ference in the structures formed at high pH, but this is not universally true. On lowering the pH, the ki-netics of gelation are affected and, in some cases, the structures underpinning the gel network are dif-ferent. Where there are differences in the self-assembled structures, the resulting gel properties are different. We therefore show isotopic control over gel properties is possible.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thomson, Miss Lisa and Adams, Dave and McAulay, Dr Kate and Fuentes Caparros, Miss Ana Maria
Authors: McAulay, K., Wang, H., Fuentes-Caparrós, A. M., Thomson, L., Khunti, N., Cowieson, N., Cui, H., Seddon, A., and Adams, D. J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Langmuir
Publisher:American Chemical Soceity
ISSN:0743-7463
ISSN (Online):1520-5827
Published Online:02 July 2020
Copyright Holders:Copyright © 2020 American Chemical Society
First Published:First published in Langmuir 36(29):8626–8631
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174004Multicomponent Supramolecular HydrogelsDave AdamsEngineering and Physical Sciences Research Council (EPSRC)EP/L021978/2Chemistry