A short peptide that preferentially binds c-MYC G-quadruplex DNA

Minard, A., Morgan, D., Raguseo, F., Di Porzio, A., Liano, D., Jamieson, A. G. and Di Antonio, M. (2020) A short peptide that preferentially binds c-MYC G-quadruplex DNA. Chemical Communications, 56(63), pp. 8940-8943. (doi: 10.1039/D0CC02954H) (PMID:32638724)

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Abstract

G-quadruplexes (G4s) are non-canonical DNA secondary structures. The identification of selective tools to probe individual G4s over the ~700,000 found in the human genome is key to unravel the biological significance of specific G4s. We took inspiration from a crystal structure of the bovine DHX36 helicase bound to the G4 formed in the promoter region of the oncogene c-MYC to identify a short peptide that preferentially binds MYC G4 with nM affinity over a small panel of parallel and antiparallel G4s tested.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morgan, Miss Danielle and Jamieson, Professor Andrew
Authors: Minard, A., Morgan, D., Raguseo, F., Di Porzio, A., Liano, D., Jamieson, A. G., and Di Antonio, M.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:01 July 2020
Copyright Holders:Copyright © 2020 The Royal Society of Chemistry
First Published:First published in Chemical Communications 56(63): 8940-8943
Publisher Policy:Reproduced under a Creative Commons licence

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