Radionuclide ventriculography phase analysis for risk stratification of patients undergoing cardiotoxic cancer therapy

Jones, K.A. , Small, A.D., Ray, S. , Hamilton, D.J. , Martin, W., Robinson, J., Goodfield, N.E.R. and Paterson, C.A. (2022) Radionuclide ventriculography phase analysis for risk stratification of patients undergoing cardiotoxic cancer therapy. Journal of Nuclear Cardiology, 29(2), pp. 581-589. (doi: 10.1007/s12350-020-02277-z) (PMID:32748278)

Abstract

Background: Accurate diagnostic tools to identify patients at risk of cancer therapy-related cardiac dysfunction (CTRCD) are critical. For patients undergoing cardiotoxic cancer therapy, ejection fraction assessment using radionuclide ventriculography (RNVG) is commonly used for serial assessment of left ventricular (LV) function. Methods: In this retrospective study, approximate entropy (ApEn), synchrony, entropy, and standard deviation from the phase histogram (phase SD) were investigated as potential early markers of LV dysfunction to predict CTRCD. These phase parameters were calculated from the baseline RNVG phase image for 177 breast cancer patients before commencing cardiotoxic therapy. Results: Of the 177 patients, 11 had a decline in left ventricular ejection fraction (LVEF) of over 10% to an LVEF below 50% after treatment had commenced. This patient group had a significantly higher ApEn at baseline to those who maintained a normal LVEF throughout treatment. Of the parameters investigated, ApEn was superior for predicting the risk of CTRCD. Combining ApEn with the baseline LVEF further improved the discrimination between the groups. Conclusions: The results suggest that RNVG phase analysis using approximate entropy may aid in the detection of sub-clinical LV contraction abnormalities, not detectable by baseline LVEF measurement, predicting a subsequent decline in LVEF.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Paterson, Mr Craig and Martin, Professor William and Jones, Dr Kirsty and Hamilton, Dr David and Ray, Professor Surajit and Robinson, Dr Jamie and Small, Dr Sandy
• Authors: Jones, K.A., Small, A.D., Ray, S., Hamilton, D.J., Martin, W., Robinson, J., Goodfield, N.E.R., and Paterson, C.A.
• College/School: College of Medical Veterinary and Life Sciences > School of Life Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Science and Engineering > School of Mathematics and Statistics > Statistics; College of Science and Engineering > School of Physics and Astronomy
• Journal Name: Journal of Nuclear Cardiology
• Publisher: Springer
• ISSN: 1071-3581
• ISSN (Online): 1532-6551
• Published Online: 03 August 2020
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in Journal of Nuclear Cardiology 29(2): 581-589
• Publisher Policy: Reproduced under a Creative Commons License