Investigating cortico-subcortical circuits during auditory sensory attenuation: a combined magnetoencephalographic and dynamic causal modelling study

Hua, L., Recasens, M., Grent-'T-Jong, T. , Adams, R. A., Gross, J. and Uhlhaas, P. J. (2020) Investigating cortico-subcortical circuits during auditory sensory attenuation: a combined magnetoencephalographic and dynamic causal modelling study. Human Brain Mapping, (doi: 10.1002/hbm.25134) (PMID:32662585) (Early Online Publication)

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Abstract

Sensory attenuation refers to the decreased intensity of a sensory percept when a sensation is self‐generated compared with when it is externally triggered. However, the underlying brain regions and network interactions that give rise to this phenomenon remain to be determined. To address this issue, we recorded magnetoencephalographic (MEG) data from 35 healthy controls during an auditory task in which pure tones were either elicited through a button press or passively presented. We analyzed the auditory M100 at sensor‐ and source‐level and identified movement‐related magnetic fields (MRMFs). Regression analyses were used to further identify brain regions that contributed significantly to sensory attenuation, followed by a dynamic causal modeling (DCM) approach to explore network interactions between generators. Attenuation of the M100 was pronounced in right Heschl's gyrus (HES), superior temporal cortex (ST), thalamus, rolandic operculum (ROL), precuneus and inferior parietal cortex (IPL). Regression analyses showed that right postcentral gyrus (PoCG) and left precentral gyrus (PreCG) predicted M100 sensory attenuation. In addition, DCM results indicated that auditory sensory attenuation involved bi‐directional information flow between thalamus, IPL, and auditory cortex. In summary, our data show that sensory attenuation is mediated by bottom‐up and top‐down information flow in a thalamocortical network, providing support for the role of predictive processing in sensory‐motor system.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter and Recasens, Dr Marc and Grent-'T-Jong, Dr Tineke and Gross, Professor Joachim and Hua, Lingling
Authors: Hua, L., Recasens, M., Grent-'T-Jong, T., Adams, R. A., Gross, J., and Uhlhaas, P. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Human Brain Mapping
Publisher:Wiley
ISSN:1065-9471
ISSN (Online):1097-0193
Published Online:14 July 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Human Brain Mapping 2020
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190713Using Magnetoencephalography to Investigate Aberrant Neural Synchrony in Prodromal Schizophrenia: A Translational Biomarker ApproachPeter UhlhaasMedical Research Council (MRC)MR/L011689/1NP - Centre for Cognitive Neuroimaging (CCNi)