Dykes, A. C., Walker, I. D.,, McMahon, A. D. , Islam, S.I.A.M. and Tait, R.C. (2001) A study of Protein S antigen levels in 3788 healthy volunteers: influence of age, sex and hormone use, and estimate for prevalence of deficiency state. British Journal of Haematology, 113(3), pp. 636-641. (doi: 10.1046/j.1365-2141.2001.02813.x) (PMID:11380449)
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Abstract
Total Protein S (tPS) and free Protein S (fPS) antigen levels were measured in 3788 healthy blood donors. Men had higher levels of both parameters than women (P < 0·001). Age had no effect on tPS in men, although there was a slight reduction in fPS levels with increasing age. In women increasing age was associated with a significant increase in tPS levels (P < 0·001) but had no effect on fPS after adjustment for menopausal state. Oral contraceptive pill (OCP) use significantly lowered tPS but had no effect on fPS. In post‐menopausal women, hormone replacement therapy (HRT) use had no statistically significant effect on either tPS or fPS. Donors with tPS or fPS levels in the lowest percentile (n = 56) were retested; only nine with repeat low levels were identified, eight of whom had persistently low levels over a 4–7‐year follow‐up. Acquired deficiency was excluded. When possible, family studies were performed, leading to an estimate of prevalence of familial PS deficiency of between 0·03% and 0·13% in the general population.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McMahon, Dr Alex and Walker, Prof Isobel and Tait, Dr Robert |
| Authors: | Dykes, A. C., Walker, I. D.,, McMahon, A. D., Islam, S.I.A.M., and Tait, R.C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | British Journal of Haematology |
| Publisher: | Blackwell Science |
| ISSN: | 0007-1048 |
| ISSN (Online): | 1365-2141 |
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