Metabolic and inflammatory functions of short-chain fatty acid receptors

Bolognini, D., Dedeo, D. and Milligan, G. (2021) Metabolic and inflammatory functions of short-chain fatty acid receptors. Current Opinion in Endocrine and Metabolic Research, 16, pp. 1-9. (doi: 10.1016/j.coemr.2020.06.005) (PMID:32835130) (PMCID:PMC7332907)

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Abstract

FFA2 and FFA3 are receptors for short-chain fatty acids which are produced in prodigious amounts by fermentation of poorly digested carbohydrates by gut bacteria. Understanding the roles of these receptors in regulating enteroendocrine, metabolic and immune functions has developed with the production and use of novel pharmacological tools and animal models. A complex (patho)physiological scenario is now emerging in which strategic expression of FFA2 and FFA3 in key cell types and selective modulation of their signalling might regulate body weight management, energy homoeostasis and inflammatory disorders.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Bolognini, Dr Daniele and Dedeo, Mr Domonkos and Milligan, Professor Graeme
Authors: Bolognini, D., Dedeo, D., and Milligan, G.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Current Opinion in Endocrine and Metabolic Research
Publisher:Elsevier
ISSN:2451-9650
ISSN (Online):2451-9650
Published Online:03 July 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Current Opinion in Endocrine and Metabolic Research 16:1-9
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
302989Defining physiological and pathophysiological roles of the Free Fatty Acid Receptor 2 by analysis of novel transgenic mouse modelsGraeme MilliganBiotechnology and Biological Sciences Research Council (BBSRC)BB/S000453/1Institute of Molecular, Cell & Systems Biology