The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases

Castelló, A. , Álvarez, E. and Carrasco, L. (2011) The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases. Journal of Biomedicine and Biotechnology, 2011, 369648. (doi: 10.1155/2011/369648) (PMID:21541224) (PMCID:PMC3085340)

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Abstract

After entry into animal cells, most viruses hijack essential components involved in gene expression. This is the case of poliovirus, which abrogates cellular translation soon after virus internalization. Abrogation is achieved by cleavage of both eIF4GI and eIF4GII by the viral protease 2A. Apart from the interference of poliovirus with cellular protein synthesis, other gene expression steps such as RNA and protein trafficking between nucleus and cytoplasm are also altered. Poliovirus 2Apro is capable of hydrolyzing components of the nuclear pore, thus preventing an efficient antiviral response by the host cell. Here, we compare in detail poliovirus 2Apro with other viral proteins (from picornaviruses and unrelated families) as regard to their activity on key host factors that control gene expression. It is possible that future analyses to determine the cellular proteins targeted by 2Apro will uncover other cellular functions ablated by poliovirus infection. Further understanding of the cellular proteins hydrolyzed by 2Apro will add further insight into the molecular mechanism by which poliovirus and other viruses interact with the host cell.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Castello, Professor Alfredo
Authors: Castelló, A., Álvarez, E., and Carrasco, L.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Journal of Biomedicine and Biotechnology
Publisher:Hindawi
ISSN:1110-7243
ISSN (Online):1110-7251
Published Online:14 April 2011
Copyright Holders:Copyright © 2011 Alfredo Castelló et al.
First Published:First published in Journal of Biomedicine and Biotechnology 2011: 369648
Publisher Policy:Reproduced under a Creative Commons License

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