Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer

Moore, S., Järvelin, A. I., Davis, I., Bond, G. L. and Castello, A. (2018) Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer. Current Opinion in Genetics and Development, 48, pp. 112-120. (doi: 10.1016/j.gde.2017.11.006) (PMID:29216518) (PMCID:PMC5894799)

Abstract

Cancer development involves the stepwise accumulation of genetic lesions that overcome the normal regulatory pathways that prevent unconstrained cell division and tissue growth. Identification of the genetic changes that cause cancer has long been the subject of intensive study, leading to the identification of several RNA-binding proteins (RBPs) linked to cancer. Cross-reference of the complement of RBPs recently identified by RNA interactome capture with cancer-associated genes and biological processes led to the identification of a set of 411 proteins with potential implications in cancer biology. These involve a broad spectrum of cellular processes including response to stress, metabolism and cell adhesion. Future studies should aim to understand these proteins and their connection to cancer from an RNA-centred perspective, holding the promise of new mechanistic understanding of cancer formation and novel approaches to diagnosis and treatment.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Castello, Professor Alfredo
• Authors: Moore, S., Järvelin, A. I., Davis, I., Bond, G. L., and Castello, A.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Current Opinion in Genetics and Development
• Publisher: Elsevier
• ISSN: 0959-437X
• ISSN (Online): 1879-0380
• Published Online: 05 December 2017
• Copyright Holders: Copyright © 2017 The Authors
• First Published: First published in Current Opinion in Genetics and Development 48: 112-120
• Publisher Policy: Reproduced under a Creative Commons License