Simpson, J. et al. (2021) Adherence to prescribed medications in patients with heart failure – insights from liquid chromatography-tandem mass spectrometry-based urine analysis. European Heart Journal: Cardiovascular Pharmacotherapy, 7(4), pp. 296-301. (doi: 10.1093/ehjcvp/pvaa071) (PMID:32597982) (PMCID:PMC8302254)
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Abstract
Aims: None of the existing studies on adherence have directly measured levels of medications (or their metabolites) in patients with heart failure. Methods and Results: We used liquid chromatography-tandem mass spectrometry to measure the presence of prescribed drugs (diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists) in the urine of patients reviewed 4 to 6 weeks after hospitalisation with heart failure. Patients were unaware that adherence was being assessed. Of the 341 patients studied, 281 (82.4%) were adherent i.e. had all prescribed drugs of interest detectable in their urine. Conversely, 60 patients (17.6%) were partially or completely non-adherent. Notably, 24 of the 60 were non-adherent to only diuretic therapy and only 7 out of all 341 patients studied (2.1%) were completely non-adherent to all prescribed heart failure drugs. There were no major differences in baseline characteristics between adherent and non-adherent patients. Conclusion: Non-adherence, assessed using a single spot urine measurement of drug levels, was confirmed in 1 of 5 patients evaluated 4 to 6 weeks after hospitalisation with heart failure.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Simpson, Dr Joanne and Jackson, Dr Colette and Jhund, Professor Pardeep and Petrie, Professor Mark and McMurray, Professor John and Gardner, Professor Roy and Haig, Dr Caroline |
Authors: | Simpson, J., Jackson, C. E., Haig, C., Jhund, P. S., Tomaszewski, M., Gardner, R. S., Tsorlalis, Y., Petrie, M. C., McMurray, J. J.V., Squire, I. B., and Gupta, P. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre |
Journal Name: | European Heart Journal: Cardiovascular Pharmacotherapy |
Publisher: | Oxford University Press |
ISSN: | 2055-6837 |
ISSN (Online): | 2055-6845 |
Published Online: | 29 June 2020 |
Copyright Holders: | Copyright © 2020 The Authors |
First Published: | First published in European Heart Journal: Cardiovascular Pharmacotherapy 7(4): 296-301 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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