The current state of peek implant osseointergration and future perspectives: a systematic review

Alotaibi, N.M. , Naudi, K.B., Conway, D.I. and Ayoub, A.F. (2020) The current state of peek implant osseointergration and future perspectives: a systematic review. European Cells and Materials, 40, pp. 1-20. (doi: 10.22203/eCM.v040a01) (PMID:32667046)

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Polyetheretherketone (PEEK) has been considered as an alternative to replace surgical metal implants. Several medical applications, including dental and orthopaedic implants, need confirmed osseointegration before functional loading. The present study aims at providing a comprehensive systematic review of the evidence on PEEK implants' osseointegration. A systematic search was conducted using Cochrane library, MEDLINE (PubMed), Ovid MEDLINE, Web of Science and EMBASE databases. Publications were identified in accordance with specific inclusion and exclusion criteria. Eligibility screening, data extraction and quality assessment were performed. The review protocol was registered in PROSPERO (CRD42018116061). A total of 55 articles were reviewed and 29 of the most relevant that met the inclusion criteria were selected. Heterogeneity was identified among the included studies. Several approaches have been applied to enhance PEEK osseointegration, with most in vivo studies conducted on small-scale animal models but no study evaluating the osseointegration of PEEK under cyclic loading. However, PEEK modifications are demonstrated to enhance osseointegration preclinically. Collectively, the present review shows a shortage of evidence, including a lack of comprehensive assessment of osseointegration, the need for large-animal-model tests, the need to assess the effect of loading on the implants and the lack of randomised controlled clinical trials.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Ayoub, Professor Ashraf and Conway, Professor David and Alotaibi, Noura Moaadi A
Authors: Alotaibi, N.M., Naudi, K.B., Conway, D.I., and Ayoub, A.F.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:European Cells and Materials
Publisher:AO Research Institute Davos
ISSN (Online):1473-2262
Published Online:01 July 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in European Cells and Materials 40:1-20
Publisher Policy:Reproduced under a Creative Commons License

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