Wilkinson, D. J., Arques, M. d. C., Huesa, C. and Rowan, A. D. (2018) Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics. British Journal of Pharmacology, 176(1), pp. 38-51. (doi: 10.1111/bph.14173) (PMID:29473950) (PMCID:PMC6284380)
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Abstract
Cartilage destruction is a key characteristic of arthritic disease, a process now widely established to be mediated by metzincins such as MMPs. Despite showing promise in preclinical trials during the 1990s, MMP inhibitors for the blockade of extracellular matrix turnover in the treatment of cancer and arthritis failed clinically, primarily due to poor selectivity for target MMPs. In recent years, roles for serine proteinases in the proteolytic cascades leading to cartilage destruction have become increasingly apparent, renewing interest in the potential for new therapeutic strategies that utilize pharmacological inhibitors against this class of proteinases. Herein, we describe key serine proteinases with likely importance in arthritic disease and highlight recent advances in this field.
| Item Type: | Articles |
|---|---|
| Additional Information: | The authors acknowledge funding from Arthritis Research UK (grant 20199) and the JGW Patterson Foundation. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Huesa, Dr Carmen |
| Authors: | Wilkinson, D. J., Arques, M. d. C., Huesa, C., and Rowan, A. D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | British Journal of Pharmacology |
| Publisher: | Wiley |
| ISSN: | 0007-1188 |
| ISSN (Online): | 1476-5381 |
| Published Online: | 23 February 2018 |
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