Cagan, R. (2016) Drug screening using model systems: some basics. Disease Models and Mechanisms, 9(11), pp. 1241-1244. (doi: 10.1242/dmm.028159) (PMID:27821602) (PMCID:PMC5117237)
|
Text
217801.pdf - Published Version Available under License Creative Commons Attribution. 304kB |
Abstract
An increasing number of laboratories that focus on model systems are considering drug screening. Executing a drug screen is complicated enough. But the path for moving initial hits towards the clinic requires a different knowledge base and even a different mindset. In this Editorial I discuss the importance of doing some homework before you start screening. 'Lead hits', 'patentable chemical space' and 'druggability' are all concepts worth exploring when deciding which screening path to take. I discuss some of the lessons I learned that may be useful as you navigate the screening matrix.
Item Type: | Articles (Editorial) |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Cagan, Professor Ross |
Authors: | Cagan, R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Disease Models and Mechanisms |
Publisher: | The Company of Biologists Ltd. |
ISSN: | 1754-8403 |
ISSN (Online): | 1754-8411 |
Copyright Holders: | Copyright © 2016 |
First Published: | First published in Disease Models and Mechanisms 9:1241-1244 |
Publisher Policy: | Reproduced under a Creative Commons licence |
University Staff: Request a correction | Enlighten Editors: Update this record