La Marca, A., Capuzzo, M., Paglia, T., Roli, L., Trenti, T. and Nelson, S. M. (2020) Testing for SARS-CoV-2 (COVID-19): a systematic review and clinical guide to molecular and serological in-vitro diagnostic assays. Reproductive BioMedicine Online, 41(3), pp. 483-499. (doi: 10.1016/j.rbmo.2020.06.001) (PMID:32651106) (PMCID:PMC7293848)
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Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated Coronavirus disease 2019 (COVID-19) pandemic has demanded rapid upscaling of in-vitro diagnostic assays to enable mass screening and testing of high-risk groups, and simultaneous ascertainment of robust data on past SARS-CoV-2 exposure at an individual and population level. To meet the exponential demand in testing, there has been an accelerated development of both molecular and serological assays across a plethora of platforms. In the present review, we discuss the current literature on these modalities including the nucleic acid amplification tests, direct viral antigen tests and the rapidly expanding laboratory based and point of care serological tests. This suite of complementary tests will inform crucial decisions by healthcare providers and policy makers and understanding their strengths and limitations will be critical to their judicious application for the development of algorithmic approaches to treatment and public health strategies.
Item Type: | Articles |
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Additional Information: | This work was supported by the National Institute for Health Research Biomedical Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol (SMN). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Nelson, Professor Scott |
Authors: | La Marca, A., Capuzzo, M., Paglia, T., Roli, L., Trenti, T., and Nelson, S. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Reproductive BioMedicine Online |
Publisher: | Elsevier |
ISSN: | 1472-6483 |
ISSN (Online): | 1472-6491 |
Published Online: | 14 June 2020 |
Copyright Holders: | Copyright © 2020 Crown Copyright |
First Published: | First published in Reproductive BioMedicine Online 41(3): 483-499 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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