Enanga, B., Ariyanayagam, M., Stewart, M. and Barrett, M. (2003) Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage. Antimicrobial Agents and Chemotherapy, 47(10), pp. 3368-3370. (doi: 10.1128/AAC.47.10.3368-3370.2003)
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Abstract
DNA damage associated with the trypanocidal activity of megazol [2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole] was shown in experiments in which DNA repair-deficient RAD51−/− Trypanosoma brucei mutants were found to be hypersensitive to the drug. Parasites resistant to megazol were selected and showed modest cross-resistance to other trypanocides, although neither drug efflux nor changes to intracellular thiols correlated with resistance.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Barrett, Professor Michael |
| Authors: | Enanga, B., Ariyanayagam, M., Stewart, M., and Barrett, M. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Antimicrobial Agents and Chemotherapy |
| Journal Abbr.: | Antimicrob Agents Chemother |
| Publisher: | American Society for Microbiology |
| ISSN: | 0066-4804 |
| ISSN (Online): | 1098-6596 |
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