3D printed polylactic acid nanocomposite scaffolds for tissue engineering applications

Alam, F., Varadarajan, K.M. and Kumar, S. (2020) 3D printed polylactic acid nanocomposite scaffolds for tissue engineering applications. Polymer Testing, 81, 106203. (doi: 10.1016/j.polymertesting.2019.106203)

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Abstract

In this study, biodegradable polylactic acid (PLA) and PLA nanocomposite scaffolds reinforced with magnetic and conductive fillers, were processed via fused filament fabrication additive manufacturing and their bioactivity and biodegradation characteristics were examined. Porous 3D architectures with 50% bulk porosity were 3D printed, and their physicochemical properties were evaluated. Thermal analysis confirmed the presence of ~18 wt% of carbon nanostructures (CNF and GNP; nowonwards CNF) and ~37 wt% of magnetic iron oxide (Fe2O3) particles in the filaments. The in vitro degradation tests of scaffolds showed porous and fractured struts after 2 and 4 weeks of immersion in DMEM respectively, although a negligible weight loss is observed. Greater extent of degradation is observed in PLA with magnetic fillers followed by PLA with conductive fillers and neat PLA. In vitro bioactivity study of scaffolds indicate enhancement from ~2.9% (PLA) to ~5.32% (PLA/CNF) and ~ 3.12% (PLA/Fe2O3). Stiffness calculated from the compression tests showed decrease from ~680 MPa (PLA) to 533 MPa and 425 MPa for PLA/CNF and PLA/Fe2O3 respectively. Enhanced bioactivity and faster biodegradation response of PLA nanocomposites with conductive fillers make them a potential candidate for tissue engineering applications such as scaffold bone replacement and regeneration.

Item Type:Articles
Additional Information:This publication is based upon work supported by the Khalifa University of Science and Technology under Award No. CIRA-2018-128.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kumar, Dr Shanmugam
Authors: Alam, F., Varadarajan, K.M., and Kumar, S.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:Polymer Testing
Publisher:Elsevier Ltd.
ISSN:0142-9418
ISSN (Online):1873-2348
Published Online:04 November 2019

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