Microarchitected 3D printed polylactic acid (PLA) nanocomposite scaffolds for biomedical applications

Alam, F., Shukla, V. R., Varadarajan, K.M. and Kumar, S. (2020) Microarchitected 3D printed polylactic acid (PLA) nanocomposite scaffolds for biomedical applications. Journal of the Mechanical Behavior of Biomedical Materials, 103, 103576. (doi: 10.1016/j.jmbbm.2019.103576) (PMID:32090905)

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Abstract

Anti-bacterial scaffolds made of copper, bronze and silver particles filled PLA nanocomposites were realized via fused filament fabrication (FFF), additive manufacturing. The thermal, mechanical and biological characteristics including bioactivity and bactericidal properties of the scaffolds were evaluated. The incorporation of bronze particles into the neat PLA increases the elastic modulus up to 10% and 27% for samples printed in 0° and 90° configurations respectively. The stiffness increases, up to 103% for silver filled PLA nanocomposite scaffolds. The surface of scaffolds was treated with acetic acid to create a thin porous network. Significant increase (~20–25%) in the anti-bacterial properties and bioactivity (~18–100%) is attributed to the synergetic effect of reinforcement of metallic/metallic alloy particles and acid treatment. The results indicate that PLA nanocomposites could be a potential candidate for bone scaffold applications.

Item Type:Articles
Additional Information:This publication is based upon work supported by the Khalifa University of Science and Technology under Award No. CIRA-2018-128.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Shanmugam, Dr Kumar
Authors: Alam, F., Shukla, V. R., Varadarajan, K.M., and Kumar, S.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:Journal of the Mechanical Behavior of Biomedical Materials
Publisher:Elsevier
ISSN:1751-6161
ISSN (Online):1878-0180
Published Online:03 December 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Journal of the Mechanical Behavior of Biomedical Materials 103:103576
Publisher Policy:Reproduced under a Creative Commons Licence

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