Cooper, A., Lovatt, M., and Nutley, M.A. (1996) Energetics of protein-cyclodextrin interactions. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 25 (1-3). pp. 85-88. ISSN 0923-0750 (doi:10.1007/BF01041542)
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The energetics of interaction of a range of cyclodextrins with folded and unfolded proteins has been examined by sensitive microcalorimetry techniques. Weak interaction with exposed amino acid residues promotes unfolding and dissociation of proteins. The possibility that such interactions may facilitate the use of cyclodextrins as ''chaperone-mimics'' in the refolding of denatured protein has been explored with the enzyme phosphoglycerate kinase. Up to 40% regain of activity can be achieved in some cases.
|Glasgow Author(s):||Nutley, Mrs Margaret and Cooper, Prof Alan|
|Authors:||Cooper, A., Lovatt, M., and Nutley, M.A.|
|Subjects:||Q Science > QD Chemistry|
Q Science > QH Natural history > QH345 Biochemistry
|College/School:||College of Science and Engineering > School of Chemistry|
|Journal Name:||Journal of Inclusion Phenomena and Molecular Recognition in Chemistry|