Energetics of protein-cyclodextrin interactions

Cooper, A., Lovatt, M. and Nutley, M.A. (1996) Energetics of protein-cyclodextrin interactions. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 25(1-3), pp. 85-88. (doi: 10.1007/BF01041542)

Full text not currently available from Enlighten.


The energetics of interaction of a range of cyclodextrins with folded and unfolded proteins has been examined by sensitive microcalorimetry techniques. Weak interaction with exposed amino acid residues promotes unfolding and dissociation of proteins. The possibility that such interactions may facilitate the use of cyclodextrins as ''chaperone-mimics'' in the refolding of denatured protein has been explored with the enzyme phosphoglycerate kinase. Up to 40% regain of activity can be achieved in some cases.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Nutley, Mrs Margaret and Cooper, Professor Alan
Authors: Cooper, A., Lovatt, M., and Nutley, M.A.
Subjects:Q Science > QD Chemistry
Q Science > QH Natural history > QH345 Biochemistry
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Inclusion Phenomena and Molecular Recognition in Chemistry

University Staff: Request a correction | Enlighten Editors: Update this record