Use of saliva for diagnosis and monitoring the SARS-CoV-2: a general perspective

Ceron, J. J., Lamy, E., Martinez-Subiela, S., Lopez-Jornet, P., Capela e Silva, F., Eckersall, P. D. and Tvarijonaviciute, A. (2020) Use of saliva for diagnosis and monitoring the SARS-CoV-2: a general perspective. Journal of Clinical Medicine, 9(5), e1491. (doi: 10.3390/jcm9051491) (PMID:32429101) (PMCID:PMC7290439)

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Abstract

In this report, updated information and future perspectives about the use of saliva as a sample for laboratory analysis of the Covid-19 are highlighted. Saliva can be used for the direct detection of the SARS-CoV-2 virus, the quantification of the specific immunoglobulins produced against it, and for the evaluation of the non-specific, innate immune response of the patient. Moreover, a deeper knowledge of potential changes in the saliva proteome in this disease may allow the identification of new diagnostic and prognostic biomarkers, or even help our understanding of the mechanisms associated with the disease. With the development of appropriate sample collection and processing methods and the use of adequate assays, saliva can provide useful clinical information about the disease and could be potentially included in guidelines for sample collection for the diagnosis, disease management, and control of Covid-19.

Item Type:Articles
Additional Information:*Funding: This work was supported by a grant from the Program for Research Groups of Excellence of the Seneca Foundation, Murcia, Spain (grant 19894/GERM/15) and “Ministerio de Economía y Competitividad”, Spain, through a post-doctoral fellowship “Ramón y Cajal” to A.T. Funding was additionally provided by the FCT– Portuguese Science Foundation, through UID/AGR/00115/2019 and research contract CEECIND/04397/2017 to E.L.
Keywords:saliva, coronavirus, SARS, Covid-19.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Eckersall, Professor David
Creator Roles:
Eckersall, D.Writing – original draft, Writing – review and editing
Authors: Ceron, J. J., Lamy, E., Martinez-Subiela, S., Lopez-Jornet, P., Capela e Silva, F., Eckersall, P. D., and Tvarijonaviciute, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Journal of Clinical Medicine
Publisher:MDPI
ISSN:2077-0383
ISSN (Online):2077-0383
Copyright Holders:Copyright © 2020 by the authors
First Published:First published in Journal of Clinical Medicine 9(5):e1491
Publisher Policy:Reproduced under a Creative Commons Licence

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