Crecente Garcia, S., Neckebroeck, A., Clark, J. S. , Smith, B. O. and Thomson, A. R. (2020) β-turn mimics by chemical ligation. Organic Letters, 22(11), pp. 4424-4428. (doi: 10.1021/acs.orglett.0c01427) (PMID:32406695) (PMCID:PMC7304061)
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Abstract
We report a simple reductive amination protocol to ligate two peptides, while simultaneously installing a β-turn mimic at the ligation junction. This strategy uses commercially available materials, mild chemical conditions, and a chemoselective ligation reaction of unprotected peptide substrates accessed through standard solid phase methods. This system was implemented in a designed β-hairpin system, and biophysical analysis demonstrates effective mimicry of the β-turn.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Clark, Professor Stephen and Thomson, Dr Drew and Crecente Garcia, Dr Selma and Neckebroeck, Albane and Smith, Dr Brian |
Authors: | Crecente Garcia, S., Neckebroeck, A., Clark, J. S., Smith, B. O., and Thomson, A. R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Science and Engineering College of Science and Engineering > School of Chemistry |
Journal Name: | Organic Letters |
Publisher: | American Chemical Society |
ISSN: | 1523-7060 |
ISSN (Online): | 1523-7052 |
Published Online: | 14 May 2020 |
Copyright Holders: | Copyright © 2020 American Chemical Society |
First Published: | First published in Organic Letters 22(11):4424-4428 |
Publisher Policy: | Reproduced under a Creative Commons licence |
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