Can nutritional interventions modulate the activation of the NLRP3 inflammasome in chronic kidney disease?

Alvarenga, L., Cardozo, L. F.M.F., Borges, N., Bengt, L., Stenvinkel, P., Shiels, P. G. , Fouque, D. and Mafra, D. (2020) Can nutritional interventions modulate the activation of the NLRP3 inflammasome in chronic kidney disease? Food Research International, 136, 109306. (doi: 10.1016/j.foodres.2020.109306)

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Abstract

Inflammatory and innate immune responses triggered by pathogen-associated and other danger-associated signals emerging during infections, results in the activation of cytosolic inflammasomes. The nod-like receptor pyrin domain containing 3 (NLRP3) is one of the inflammasomes mediating such responses through the activation of caspase-1, which increases the production and release of pro-inflammatory cytokines, such as IL-1β and IL-18 and induces programmed cell death through pyroptosis. NLRP3 is thought to play a crucial role in the underlying inflammatory responses in many lifestyles related chronic diseases. Consequently, research on the NLRP3 inflammasome has expanded dramatically in recent years. Although several studies have investigated the role of NLRP3 activation in chronic kidney disease (CKD), few studies have evaluated strategies to modulate its activation by means of interventions using non-pharmacological strategies. This review discusses some nutritional strategies (bioactive compounds, probiotics and caloric restriction) that have been shown to influence NLRP3 in experimental models of renal disease, and in CKD. It discusses how nutritional interventions could potentially dampen NLRP3 associated inflammatory burden, as part of nutritional strategies to prevent and treat CKD and its complications.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Shiels, Professor Paul
Authors: Alvarenga, L., Cardozo, L. F.M.F., Borges, N., Bengt, L., Stenvinkel, P., Shiels, P. G., Fouque, D., and Mafra, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Food Research International
Publisher:Elsevier
ISSN:0963-9969
ISSN (Online):1873-7145
Published Online:16 May 2020
Copyright Holders:Copyright © 2020 Elsevier Ltd
First Published:First published in Food Research International 136:109306
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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