The European Research Network on Signal Transduction (ERNEST): toward a multidimensional holistic understanding of G protein-coupled receptor signaling

Sommer, M. E. et al. (2020) The European Research Network on Signal Transduction (ERNEST): toward a multidimensional holistic understanding of G protein-coupled receptor signaling. ACS Pharmacology and Translational Science, 3(2), pp. 361-370. (doi: 10.1021/acsptsci.0c00024) (PMID:32296774) (PMCID:PMC7155379)

[img] Text
215053.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

1MB

Abstract

G protein-coupled receptors (GPCRs) are intensively studied due to their therapeutic potential as drug targets. Members of this large family of transmembrane receptor proteins mediate signal transduction in diverse cell types and play key roles in human physiology and health. In 2013 the research consortium GLISTEN (COST Action CM1207) was founded with the goal of harnessing the substantial growth in knowledge of GPCR structure and dynamics to push forward the development of molecular modulators of GPCR function. The success of GLISTEN, coupled with new findings and paradigm shifts in the field, led in 2019 to the creation of a related consortium called ERNEST (COST Action CA18133). ERNEST broadens focus to entire signaling cascades, based on emerging ideas of how complexity and specificity in signal transduction are not determined by receptor–ligand interactions alone. A holistic approach that unites the diverse data and perspectives of the research community into a single multidimensional map holds great promise for improved drug design and therapeutic targeting.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tobin, Andrew
Authors: Sommer, M. E., Selent, J., Carlsson, J., De Graaf, C., Gloriam, D. E., Keseru, G. M., Kosloff, M., Mordalski, S., Rizk, A., Rosenkilde, M. M., Sotelo, E., Tiemann, J. K.S., Tobin, A., Vardjan, N., Waldhoer, M., and Kolb, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:ACS Pharmacology and Translational Science
Publisher:American Chemical Society
ISSN:2575-9108
ISSN (Online):2575-9108
Published Online:31 March 2020
Copyright Holders:Copyright © 2020 American Chemical Society
First Published:First published in ACS Pharmacology and Translational Science 3(2): 361-370
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record