COVID-19 Pandemic – a focused review for clinicians

Cevik, M., Bamford, C. and Ho, A. (2020) COVID-19 Pandemic – a focused review for clinicians. Clinical Microbiology and Infection, 26(7), pp. 842-847. (doi: 10.1016/j.cmi.2020.04.023) (PMID:32344166) (PMCID:PMC7182753)

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Abstract

Background: The COVID-19 pandemic caused by SARS-CoV-2 remains a significant issue for global health, economics and society. A wealth of data has been generated since its emergence in December 2019, and it is vital for clinicians to keep up with this data from across the world at a time of uncertainty and constantly evolving guidelines and clinical practice. Objectives: Here we provide an update for clinicians on the recent developments in the virology, diagnostics, clinical presentation, viral shedding, and treatment options for COVID-19 based on current literature. Sources: We considered published peer-reviewed papers and non-peer-reviewed pre-print manuscripts on COVID19 and related aspects with an emphasis on clinical management aspects. Content: We describe the virological characteristics of SARS-CoV-2 and the clinical course of COVID-19 with an emphasis on diagnostic challenges, duration of viral shedding, severity markers and current treatment options. Implications: The key challenge in managing COVID-19 remains patient density. However, accurate diagnosis as well as early identification and management of high-risk severe cases are important for many clinicians. For improved management of cases, there is a need to understand test probability of serology, qRT-PCR and radiological testing, and the efficacy of available treatment options that could be used in severe cases with a high risk of mortality.

Item Type:Articles
Keywords:Coronavirus, COVID-19, novel coronavirus, SARS-CoV-2.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ho, Dr Antonia
Authors: Cevik, M., Bamford, C., and Ho, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Clinical Microbiology and Infection
Publisher:Elsevier
ISSN:1198-743X
ISSN (Online):1469-0691
Published Online:25 April 2020
Copyright Holders:Copyright © 2020 European Society of Clinical Microbiology and Infectious Diseases
First Published:First published in Clinical Microbiology and Infection 26(7): 842-847
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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