Evaluation of personal protection afforded by repellent-treated sandals against mosquito bites in south-eastern Tanzania

Sangoro, O. P., Gavana, T., Finda, M., Mponzi, W., Hape, E., Limwagu, A., Govella, N. J., Chaki, P. and Okumu, F. O. (2020) Evaluation of personal protection afforded by repellent-treated sandals against mosquito bites in south-eastern Tanzania. Malaria Journal, 19, p. 148. (doi: 10.1186/s12936-020-03215-7) (PMID:32268907) (PMCID:PMC7140554)

Abstract

Outdoor and early evening mosquito biting needs to be addressed if malaria elimination is to be achieved. While indoor-targeted interventions, such as insecticide-treated nets and indoor residual spraying, remain essential, complementary approaches that tackle persisting outdoor transmission are urgently required to maximize the impact. Major malaria vectors principally bite human hosts around the feet and ankles. Consequently, this study investigated whether sandals treated with efficacious spatial repellents can protect against outdoor biting mosquitoes. Sandals affixed with hessian bands measuring 48 cm treated with 0.06 g, 0.10 g and 0.15 g of transfluthrin were tested in large cage semi-field and full field experiments. Sandals affixed with hessian bands measuring 240 cm and treated with 0.10 g and 0.15 g of transfluthrin were also tested semi field experiments. Human landing catches (HLC) were used to assess reduction in biting exposure by comparing proportions of mosquitoes landing on volunteers wearing treated and untreated sandals. Sandals were tested against insectary reared Anopheles arabiensis mosquitoes in semi-field experiments and against wild mosquito species in rural Tanzania. In semi-field tests, sandals fitted with hessian bands measuring 48 cm and treated with 0.15 g, 0.10 g and 0.06 g transfluthrin reduced mosquito landings by 45.9%, (95% confidence interval (C.I.) 28-59%), 61.1% (48-71%), and 25.9% (9-40%), respectively compared to untreated sandals. Sandals fitted with hessian bands measuring 240 cm and treated with 0.15 g and 0.10 g transfluthrin reduced mosquito landings by 59% (43-71%) and 64% (48-74%), respectively. In field experiments, sandals fitted with hessian bands measuring 48 cm and treated with 0.15 g transfluthrin reduced mosquito landings by 70% (60-76%) against Anopheles gambiae sensu lato, and 66.0% (59-71%) against all mosquito species combined. Transfluthrin-treated sandals conferred significant protection against mosquito bites in semi-field and field settings. Further evaluation is recommended for this tool as a potential complementary intervention against malaria. This intervention could be particularly useful for protecting against outdoor exposure to mosquito bites. Additional studies are necessary to optimize treatment techniques and substrates, establish safety profiles and determine epidemiological impact in different settings.

• Item Type: Articles
• Additional Information: Funding: This study was supported by Stars in Global Health; Grand Challenges Canada, Grant number S5-0442-01 which was granted to OS. FOO was also supported by a Wellcome Trust Intermediate Research Fellowship (Grant number: WT102350/Z/13/Z).
• Keywords: Ifakara, New tools, Residual malaria transmission, Transfluthrin, Transfluthrin-treated footwear, Vector borne diseases
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Okumu, Professor Fredros and Govella, Dr Nicodem
• Authors: Sangoro, O. P., Gavana, T., Finda, M., Mponzi, W., Hape, E., Limwagu, A., Govella, N. J., Chaki, P., and Okumu, F. O.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Malaria Journal
• Publisher: BMC
• ISSN: 1475-2875
• ISSN (Online): 1475-2875
• Copyright Holders: Copyright © The Author(s) 2020
• First Published: First published in Malaria Journal 19:148
• Publisher Policy: Reproduced under a Creative Commons licence