Popadynec, M., Clark, J. S. and Gibbard, H. (2020) Bidirectional synthesis of the IJK fragment of ciguatoxin CTX3C by sequential double ring-closing metathesis and Tsuji-Trost allylation. Organic Letters, 22(9), pp. 3734-3738. (doi: 10.1021/acs.orglett.0c01238) (PMID:32306737) (PMCID:PMC7304930)
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Abstract
A novel four-step bidirectional strategy has been used to synthesize the IJK fragment of the marine polyether natural product CTX3C from a simple monocyclic precursor in a concise and efficient manner. The four-step bidirectional sequence involves ring-closing metathesis, alcohol oxidation, enol carbonate formation, and palladium-mediated Tsuji–Trost allylation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Clark, Professor Stephen and Popadynec, Michael |
Authors: | Popadynec, M., Clark, J. S., and Gibbard, H. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Organic Letters |
Publisher: | American Chemical Society |
ISSN: | 1523-7060 |
ISSN (Online): | 1523-7052 |
Published Online: | 19 April 2020 |
Copyright Holders: | Copyright © 2020 American Chemical Society |
First Published: | First published in Organic Letters 22(9): 3734-3738 |
Publisher Policy: | Reproduced under a Creative Commons license |
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